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Image Search Results
Journal: The Journal of Neuroscience
Article Title: Chronic Mild Stress during Gestation Worsens Neonatal Brain Lesions in Mice
doi: 10.1523/JNEUROSCI.5330-06.2007
Figure Lengend Snippet: A–D, Effects of CUMS on excitotoxic brain lesions induced by ibotenate (A–D), NMDA (E, F), or S-bromowillardiine (G, H) in C57BL/6 mice. Excitotoxins were injected at P5, and pups were killed at P10. Bars represent mean sagittal diameter (A, C, E, G) or mean volume (B, D, F, H) of the lesions ± SEM. Asterisks indicate statistically significant difference from control males (A–D) or controls (E–H). *p < 0.05, **p < 0.01, ***p < 0.001 in three-way ANOVA with contrasts (A–G) or in Student's t test (E–H). Ctrl, Control.
Article Snippet: Excitotoxic lesions and lesion size determination Excitotoxic brain lesions were induced by injecting 10 μg of ibotenate (NMDA and metabotropic receptor agonist; Tocris Bioscience, Bristol, UK), 5 μg of NMDA (NMDA receptor agonist;
Techniques: Injection
Journal: The Journal of Neuroscience
Article Title: Chronic Mild Stress during Gestation Worsens Neonatal Brain Lesions in Mice
doi: 10.1523/JNEUROSCI.5330-06.2007
Figure Lengend Snippet: Real-time PCR quantification of glucocorticoid receptor (GR) mRNA. Pups from control (Ctrl) and GR-I unstressed B6C3F1 mothers were killed at P0 or P5. Brains were removed, and cortical plate (A) and underlying white matter (B) immediately adjacent to the normal site of excitotoxin injection were collected for RNA extraction. Bars represent mean GR/β2-microglobulin ratios ± SEM. Asterisks indicate statistically significant differences between Ctrl pups from unstressed mothers and pups from mothers exposed to CUMS. *p < 0.05, **p < 0.01, ***p < 0.001 in ANOVA with Dunnett's test.
Article Snippet: Excitotoxic lesions and lesion size determination Excitotoxic brain lesions were induced by injecting 10 μg of ibotenate (NMDA and metabotropic receptor agonist; Tocris Bioscience, Bristol, UK), 5 μg of NMDA (NMDA receptor agonist;
Techniques: Real-time Polymerase Chain Reaction, Injection, RNA Extraction